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Aerial view of UCSD campus looking South

Geisel Library - Nobel Laureates at UCSD

Discovery of new atmospheric reaction garners prize

Urey Hall Addition

Pacific Hall

Natural Sciences Building

The crystal structure of a group II intron in the pre-catalytic state

Geisel Library Walk

York Hall

Structure of an inhibitor of hepatitis C virus protein synthesis bound to its target in the viral ribonucleic acid (RNA) genome

ANCA probe staining amyloid plaques derived from Alzheimer’s-related Aβ peptides fluoresces as green and as yellow when derived from prion proteins (PrPSC)

Price Center

Generation of bio-resistive surface coatings on amyloids inhibits harmful protein-amyloid interactions associated with Alzheimer disease

Proposed schematic models of the interfacial binding surface of four different members of the Phospholipase A2 superfamily

Urey Hall and Pacific Hall

Characterization of the "inhibitor binding pocket" in the catalytic domain of the calcium-independent phospholipase A2 with residues within a 5 A raidus of the inhibitor shown

A Crystalline Singlet Phosphinonitrene: a Nitrogen Atom Transfer Agent

Mayer Hall

Drug candidate in orange envelope bound to UPPS

Possible binding modes for phospholipase A2 via its membrane interaction site, another allosteric site, and its catalytic site



News

Toor Lab's Anastassia Gomez Selected As 2015 HHMI Gilliam Fellow
Chemistry & Biochemistry graduate student, Anastassia Gomez, a member of the Toor Lab, has been selected a 2015 Howard Hughes Medical Institute (HHMI) Gilliam Fellow. There are only 30 candidates named annually to the HHMI national fellowship. Criteria for selection include academic excellence, scientific potential, and commitment to the advancement of diversity and inclusion, in the sciences. The prestigious HHMI Gilliam Fellowship provides graduate school support for up to three years to help each fellow move toward a career in science research and teaching. Congratulations Anastassia!

NSF Survey Ranks UC San Diego's Chemistry & Biochemistry Research Spending No. 5 in the U.S.
Academic research spending by UC San Diego's Department of Chemistry & Biochemistry totaled $31.4 Million in FY2013, 5th highest for U.S. research universities and colleges in 2013, compared to $27.4 Million and 8th highest for U.S. research universities and colleges in FY 2012. Federally funded research support accounted for 85.2% and 83.2% of FY2013 and FY2012 Chemistry & Biochemistry R&D expenditures, respectively. The data and rankings were published as part of the National Science Foundation's (NSF) Higher Education Research & Development (HERD) Survey for Fiscal Year 2013 (its most recent report). The HERD Survey is an annual census and the primary source of information on R&D expenditures at U.S. colleges and universities; it collects information on R&D expenditures by field of research, types of research and expenses, and sources of funds. To access the full survey article click here

Gianneschi Group Designs First Enzyme-Responsive Nanoparticle Delivering Chemotherapeutics to Tumors
Researchers from the Gianneschi Group and UC San Diego's Moores Cancer Center have successfully engineered the first nanoscale therapeutic drug delivery system targeting cancer tumors utilizing the enzyme-directed assembly of a responsive nanoparticle. This targeting approach represents a significant departure from known methods of active or passive targeting to tumors. The work builds upon Professor Nathan Gianneschi's patent pending, Enzyme Directed Assembly of Particle Theranostic (Edapt),technology. Their research article published in the journal Advanced Materials (07/14/2015 Issue). Congratulations Gianneschi Group! To access the full research article click here

Professor Cohen Named American Chemical Society Fellow
The American Chemical Society (ACS) has selected Professor Seth M. Cohen as a 2015 ACS Fellow. The ACS Fellows Program recognizes and honors individuals for their outstanding achievements in, and contributions to, the science and the profession and for their equally exemplary service to the community. Professor Cohen was named a 2015 Fellow for extraordinary achievements in research including his pioneering research with metalloprotein inhibitors and advancements in modification methods for metal-organic frameworks; and also for his service contributions as Treasurer of the Division of Inorganic Chemistry and Advisory Board Member of C&EN. Congratulations Seth!

Devaraj Lab Leads Development of Synthetic Cell Membranes That Grow Like Living Cells
Researchers from Professor Neal Devaraj’s Lab and The BioCircuits Institute have designed and synthesized the first artificial cell membrane capable of sustaining continual growth, just like a living cell. The artificial cell membrane continually synthesizes all of the components needed to form additional catalytic membranes mimicking nature’s ability to support phospholipid membrane formation. To develop the growing membrane the researchers substituted a complex network of biochemical pathways with a single autocatalyst that simultaneously drives membrane growth. Their achievement provides an important new tool for synthetic biology and origin of life studies. Their research paper was published in the 6/22/15 early edition of the Proceedings of the National Academy of Sciences. Congratulations to the Devaraj Lab and The BioCircuits Institute! To access the full research report click here

Researchers from Gianneschi & Cohen Groups First to Image Nanostructure Formations in Real Time
Professor Nathan Gianneschi and Chair Seth Cohen of UC San Diego's Department of Chemistry and Biochemistry co-led a team of researchers from UC San Diego, Florida State and Pacific Northwest National Labs that, for the first time, visualized the growth of nanoscale chemical complexes in real time. The ground-breaking research employed a recently developed process called Liquid Cell Transmission Electron Microscopy (LCTEM) that provided scientists an unprecedented understanding of the stepwise formation of nanostructures. Their research paper was published in the 'Journal of the American Chemical Society' (6/8/2015 online edition). Congratulations to the Gianneschi and Cohen Groups! To read the full research article click here

Gianneschi Group Develops Bio-Inspired Nano Materials That Produce Structural Colors
Structural colors arise from the interaction of light with materials that have patterns on a minute scale. The natural structure of melanosomes (tiny packets of melanin) that produce structural colors in bird feathers inspired the efforts of a team of researchers from UC San Diego (the Gianneschi Group), the University of Akron and Scripps Institution of Oceanography, to fabricate colored films with colors determined by physical structures rather than by pigments. The team created the colored films by synthesizing various concentrations of polydopamine-based synthetic melanin nanoparticles (SMNPs) that were then evaporated into thin layers that mimicked the natural structures found in bird feathers. The SMNP films interacted with light to create pure hues of color ranging from red to green. The new SMNP materials have broad applicability in colorimetric sensors, full color displays, and photonic pigments. The research team’s findings were documented in a paper published in the 5/26/2015 issue of ‘ACS NANO'. Congratulations to the Gianneschi Group and the entire research team! To access the full research report click here

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Message from the Chair

Partho Ghosh, Chair



Faculty Spotlight

View profile for Kim Albizati
Kim Albizati

Chemical Education

View profile for Rommie E. Amaro
Rommie E. Amaro

Computational Chemistry and Biophysics

View profile for Timothy Baker
Timothy Baker

Macromolecular, cryoelectron microscopy and three-dimensional, image-reconstruction techniques.

View profile for Stacey Brydges
Stacey Brydges

Chemical Education: Development of context-rich curriculum; Use of collaborative learning strategies in large lectures; Communication of chemistry

View profile for Michael Burkart
Michael Burkart

Natural product synthesis/biosynthesis, Biological chemistry and enzymology, Metabolic engineering.

View profile for Thomas Bussey
Thomas Bussey

Chemical Education: Visual Literacy in Science, Biochemistry Education, Nano Science Education, K-20 Professional Development, and STEM Career Development

View profile for Seth Cohen
Seth Cohen

Bioinorganic and coordination chemistry. Metalloprotein inhibitors and supramolecular materials.

View profile for Robert Continetti
Robert Continetti

Dissociation dynamics of transient species, three-body reaction dynamics, novel mass-spectrometric methods

View profile for John Crowell
John Crowell

Materials chemistry, surface kinetics of metals/semiconductors, CVD, photo-induced deposition, thin-film spectroscopy.

View profile for Edward Dennis
Edward Dennis

Biochemistry: phospholipase A2, signal transduction in macrophages, lipid maps, prostaglandin regulation, mass spec of lipids and proteins.

View profile for Neal Devaraj
Neal Devaraj

Biomimetic Chemistry, Molecular Imaging, Electrochemistry

View profile for Jack Dixon
Jack Dixon

Protein Tyrosine Phosphatase, Dual=specific Phosphatase, PTEN

View profile for Daniel Donoghue
Daniel Donoghue

Fibroblast Growth Factor Receptors (FGFRs) in Human Cancer

View profile for Josh Figueroa
Josh Figueroa

Inorganic and Organometallic Chemistry: Synthesis, Small Molecule Activation and New Transformations.

View profile for Misha Galperin
Misha Galperin

Electron Transport in Condensed Phases. Dissipation and Relaxation Processes. Non-equilibrium Open Quantum Systems. Molecular Electronics.

View profile for Gouri Ghosh
Gouri Ghosh

Biochemistry and biophysics: transcription, signaling, pre-mRNA splicing, mRNA transport, protein-protein, protein-DNA and protein-RNA interactions

View profile for Partho Ghosh
Partho Ghosh

Mechanisms of bacterial and protozoan pathogenesis, and host response against infectious microbes.

View profile for Nathan Gianneschi
Nathan Gianneschi

Bioorganic chemistry, Supramolecular Chemistry, Bionanotechnology, Materials, Synthesis

View profile for Kamil Godula
Kamil Godula

Nanotechnologies for analysis of glycan function during development. Glycomaterials for stem cell-based tissue regeneration.

View profile for Thomas Hermann
Thomas Hermann

RNA as a Drug Target.

View profile for Patricia Jennings
Patricia Jennings

Biophysical chemistry: protein structure, dynamics and folding; 2, 3 and 4D NMR spectroscopy; PCR; equilibrium and kinetic-fluorescence, absorbance and circular dichroism spectroscopies

View profile for Simpson Joseph
Simpson Joseph

Molecular Mechanism of Protein Synthesis

View profile for Judy Kim
Judy Kim

Biophysical chemistry: Spectroscopic studies of membrane protein folding and dynamics

View profile for Elizabeth Komives
Elizabeth Komives

Structure, function, dynamics and thermodynamics of protein-protein interactions: NMR, mass spectrometry and kinetics

View profile for Clifford Kubiak
Clifford Kubiak

Inorganic, materials, and physical chemistry: electron transfer, catalysis, fixation and utilization of carbon dioxide.

View profile for Andrew Kummel
Andrew Kummel

STM/STS of gate oxides on compound semiconductors and adsorbates on organic semiconductor

View profile for Katja Lindenberg
Katja Lindenberg

Theoretical chemical physics: non-equilibrium statistical mechanics; stochastic processes; nonlinear phenomena; complex systems; condensed matter.

View profile for J. Andrew McCammon
J. Andrew McCammon

Statistical mechanics and computational chemistry, with applications to biological systems

View profile for Mario Molina
Mario Molina

Physical Chemistry: Gas Phase Chemical Kinetics and Photochemistry; Chemistry of Atmospheric Aerosols; Air Pollution in Megacities of the Developing World

View profile for Tadeusz Molinski
Tadeusz Molinski

Organic chemistry of marine natural products, synthesis, NMR, and biomedical applications

View profile for Uli Müller
Uli Müller

Evolution of catalytic RNAs, and the Origin of Life

View profile for Joseph O'Connor
Joseph O'Connor

Organotransition metal; organic; physical organic; bioorganometallic; synthetic; and inorganic chemistry

View profile for Stanley Opella
Stanley Opella

NMR structural studies of proteins in membranes and other supramolecular assemblies

View profile for Francesco Paesani
Francesco Paesani

Theoretical chemical physics of complex interfaces of relevance to the environment

View profile for Charles Perrin
Charles Perrin

Physical-organic chemistry: stereoelectronic effects; hydrogen bonding; isotope effects; ionic solvation; naked anions; malonic anhydrides

View profile for Robert Pomeroy
Robert Pomeroy

The application of analytical chemistry to forensic, environmental and industrial chemistry, then bridge these experiences into the classroom. This also includes the role technology and instrumentation play in discovery and problem solving.

View profile for Kimberly Prather
Kimberly Prather

Environmental, physical/analytical chemistry: gas/particle processes of tropospheric significance; mass spectrometry; laser-based analysis techniques.

View profile for Arnold Rheingold
Arnold Rheingold

Inorganic chemistry: Small-molecule crystallography, synthesis of transition metal/p-block clusters

View profile for Jeffrey Rinehart
Jeffrey Rinehart

Inorganic, materials, and magnetochemistry

View profile for Michael Sailor
Michael Sailor

Nanomaterials: porous silicon, chemical and biological sensors, biomaterials, electrochemistry

View profile for Barbara Sawrey
Barbara Sawrey

Chemical education: development of computer-based multimedia to assist student learning of complex scientific processes and concepts

View profile for Amitabha Sinha
Amitabha Sinha

Experimental physical chemistry: photochemistry; laser spectroscopy; reaction dynamics of vibrationally excited molecules

View profile for Michael Tauber
Michael Tauber

Physical chemistry; Optical and magnetic spectroscopy; Fundamental studies of charge transport and solvation; Applications to energy conversion and energy storage.

View profile for Susan Taylor
Susan Taylor

Structure, Function, Dynamics, and Localization of PKA as a Prototype for the Protein Kinase Superfamily.

View profile for Akif Tezcan
Akif Tezcan

Bioinorganic and biophysical chemistry; Metalloprotein structure, function and biosynthesis; Biomaterials

View profile for Emmanuel Theodorakis
Emmanuel Theodorakis

Synthetic, Medicinal, Bioorganic and Biological Chemistry, Methods and Strategies in Natural Products Chemistry

View profile for Mark Thiemens
Mark Thiemens

Atmospheric chemistry: physical chemistry of isotope effects; solar system formation

View profile for Navtej Toor
Navtej Toor

Structure and Function of Introns and Retroelements

View profile for Yitzhak Tor
Yitzhak Tor

Ligand-nucleic acid interactions; Antiviral and antibacterial agents; Fluorescent nucleosides and nucleotides; Cellular delivery vehicles

View profile for William Trogler
William Trogler

Inorganic chemistry: polymer chemistry; nanomaterials.

View profile for Roger Tsien
Roger Tsien

Chemical biology; design, synthesis, and application of molecular probes of biological function

View profile for Robert Tukey
Robert Tukey

Environmental toxicology: The role of environmental and chemical toxicants on gene expression

View profile for Elizabeth Villa
Elizabeth Villa

Structural Cell Biology, Cryo-Electron Microscopy, Multiscale modeling

View profile for Wei Wang
Wei Wang

epigenomics, cellular reprogramming, protein recognition, computational biology, systems biology

View profile for John Weare
John Weare

Physical chemistry: calculations of the dynamics of complex systems; theoretical geochemistry

View profile for Haim Weizman
Haim Weizman

Chemical education, Bioorganic chemistry

View profile for Roy Wollman
Roy Wollman

Spatio-temporal signaling control of biological self-organization. Signaling networks in innate immunity. Microscopy; Mathematical modeling; Computational image analysis; Systems Biology.

View profile for Wei Xiong
Wei Xiong

Investigation of charge transfer mechanism in nanomaterials with novel ultrafast spectroscopies

View profile for Jerry Yang
Jerry Yang

Bioorganic Chemistry, Molecular Self-Assembly, Molecular Synthesis, Materials Chemistry, Bionanotechnology

View profile for Joel Yuen Zhou
Joel Yuen Zhou

Theory at the interface of chemistry, condensed matter, and materials physics


Events and Seminars

09/02/2015 (Wed) at 11:00 AM
Organic Seminar
Dr. Cristian A. Strassert
Finding and Tuning (Supra) Molecular Set-Screws in (Electro)Luminescent Metal Complexes
09/03/2015 (Thu) at 10:00 AM
Thesis Defense
James Michael Brady
Constraining air pollutant emissions through in situ measurement and novel instrumentation
09/09/2015 (Wed) at 01:00 PM
Department Colloquia
Professor Kim Albizati
TBA
09/14/2015 (Mon) at 04:00 PM
Department Colloquia
Professor Roy Wollman
TBA
09/28/2015 (Mon) at 11:00 AM
Organic Seminar
Professor Donna G. Blackmond
Models for the Origin of Biological Homochirality
09/29/2015 (Tue) at 12:00 PM
Department Colloquia
Professor Haim Weizman
TBA
10/01/2015 (Thu) at 12:00 PM
Biochemistry Seminar
Professor Jennifer Doudna
TBA
More....