Aerial view of UCSD campus looking South
Geisel Library - Nobel Laureates at UCSD
Discovery of new atmospheric reaction garners prize
Natural Sciences Building
The crystal structure of a group II intron in the pre-catalytic state
Structure of an inhibitor of hepatitis C virus protein synthesis bound to its target in the viral ribonucleic acid (RNA) genome
ANCA probe staining amyloid plaques derived from Alzheimer’s-related Aβ peptides fluoresces as green and as yellow when derived from prion proteins (PrPSC)
Generation of bio-resistive surface coatings on amyloids inhibits harmful protein-amyloid interactions associated with Alzheimer disease
Proposed schematic models of the interfacial binding surface of four different members of the Phospholipase A2 superfamily
Urey Hall and Pacific Hall
Characterization of the "inhibitor binding pocket" in the catalytic domain of the calcium-independent phospholipase A2 with residues within a 5 A raidus of the inhibitor shown
A Crystalline Singlet Phosphinonitrene: a Nitrogen Atom Transfer Agent
Drug candidate in orange envelope bound to UPPS
Possible binding modes for phospholipase A2 via its membrane interaction site, another allosteric site, and its catalytic site
Chemistry & Biochemistry graduate student, Anastassia Gomez, a member of the Toor Lab, has been selected a 2015 Howard Hughes Medical Institute (HHMI) Gilliam Fellow. There are only 30 candidates named annually to the HHMI national fellowship. Criteria for selection include academic excellence, scientific potential, and commitment to the advancement of diversity and inclusion, in the sciences. The prestigious HHMI Gilliam Fellowship provides graduate school support for up to three years to help each fellow move toward a career in science research and teaching. Congratulations Anastassia!
Academic research spending by UC San Diego's Department of Chemistry & Biochemistry totaled $31.4 Million in FY2013, 5th highest for U.S. research universities and colleges in 2013, compared to $27.4 Million and 8th highest for U.S. research universities and colleges in FY 2012. Federally funded research support accounted for 85.2% and 83.2% of FY2013 and FY2012 Chemistry & Biochemistry R&D expenditures, respectively. The data and rankings were published as part of the National Science Foundation's (NSF) Higher Education Research & Development (HERD) Survey for Fiscal Year 2013 (its most recent report). The HERD Survey is an annual census and the primary source of information on R&D expenditures at U.S. colleges and universities; it collects information on R&D expenditures by field of research, types of research and expenses, and sources of funds.
To access the full survey article click here
Researchers from the Gianneschi Group and UC San Diego's Moores Cancer Center have successfully engineered the first nanoscale therapeutic drug delivery system targeting cancer tumors utilizing the enzyme-directed assembly of a responsive nanoparticle. This targeting approach represents a significant departure from known methods of active or passive targeting to tumors. The work builds upon Professor Nathan Gianneschi's patent pending, Enzyme Directed Assembly of Particle Theranostic (Edapt),technology. Their research article published in the journal Advanced Materials (07/14/2015 Issue). Congratulations Gianneschi Group! To access the full research article click here
The American Chemical Society (ACS) has selected Professor Seth M. Cohen as a 2015 ACS Fellow. The ACS Fellows Program recognizes and honors individuals for their outstanding achievements in, and contributions to, the science and the profession and for their equally exemplary service to the community. Professor Cohen was named a 2015 Fellow for extraordinary achievements in research, including his discovery of metalloprotein inhibitors, for which he holds a U.S. Patent, and advancements in modification methods for metal-organic frameworks; and also for his service contributions as Treasurer of the Division of Inorganic Chemistry and Advisory Board Member of C&EN. Congratulations Seth!
Researchers from Professor Neal Devaraj’s Lab and The BioCircuits Institute have designed and synthesized the first artificial cell membrane capable of sustaining continual growth, just like a living cell. The artificial cell membrane continually synthesizes all of the components needed to form additional catalytic membranes mimicking nature’s ability to support phospholipid membrane formation. To develop the growing membrane the researchers substituted a complex network of biochemical pathways with a single autocatalyst that simultaneously drives membrane growth. Their achievement provides an important new tool for synthetic biology and origin of life studies. Their research paper was published in the 6/22/15 early edition of the Proceedings of the National Academy of Sciences. Congratulations to the Devaraj Lab and The BioCircuits Institute! To access the full research report click here
Professor Nathan Gianneschi and Chair Seth Cohen of UC San Diego's Department of Chemistry and Biochemistry co-led a team of researchers from UC San Diego, Florida State and Pacific Northwest National Labs that, for the first time, visualized the growth of nanoscale chemical complexes in real time. The ground-breaking research employed a recently developed process called Liquid Cell Transmission Electron Microscopy (LCTEM) that provided scientists an unprecedented understanding of the stepwise formation of nanostructures. Their research paper was published in the 'Journal of the American Chemical Society' (6/8/2015 online edition). Congratulations to the Gianneschi and Cohen Groups! To read the full research article click here
Structural colors arise from the interaction of light with materials that have patterns on a minute scale. The natural structure of melanosomes (tiny packets of melanin) that produce structural colors in bird feathers inspired the efforts of a team of researchers from UC San Diego (the Gianneschi Group), the University of Akron and Scripps Institution of Oceanography, to fabricate colored films with colors determined by physical structures rather than by pigments.
The team created the colored films by synthesizing various concentrations of polydopamine-based synthetic melanin nanoparticles (SMNPs) that were then evaporated into thin layers that mimicked the natural structures found in bird feathers. The SMNP films interacted with light to create pure hues of color ranging from red to green. The new SMNP materials have broad applicability in colorimetric sensors, full color displays, and photonic pigments. The research team’s findings were documented in a paper published in the 5/26/2015 issue of ‘ACS NANO'. Congratulations to the Gianneschi Group and the entire research team! To access the full research report click here