Wang, Wei
epigenomics, cellular reprogramming, protein recognition, computational biology, systems biology

Contact Information
Professor of Chemistry and Biochemistry
Professor of Cellular and Molecular Medicine

Office: Urey Hall 4254
Phone: 858-822-4240
Group: View group members
2000 Ph.D., Biophysics, University of California, San Francisco
1996 M.S., Physics, University of Miami
1993 B.S., Physics, Tsinghua University
Awards and Academic Honors
Postdoctoral Fellow, Stanford University
American Chemical Society CCG Excellence Award
Research Interests
We are interested in understanding the regulatory mechanisms underlying cell fate decision. Especially, we take a multi-scale approach that integrates computational and experimental investigation of epigenetic regulation in cell fate decision from molecular level to genomic level then to systems level. We aim to build computational and theoretical models to uncover fundamental principles that govern cell fate decision in development and cellular reprogramming and design strategies to intelligently manipulate cell state.

Our research is highly interdisciplinary. The methods we use range from molecular modeling of protein structures, to bioinformatics analysis of epigenomic data generated by sequencing technology, to statistical learning of genetic network, to biophysical modeling of epigenetic landscape. The theoretical work is tightly coupled with experimental investigation that exploits molecular biology, biochemistry, cell biology and genomic techniques.
Primary Research Area
Interdisciplinary interests
Computational and Theoretical

Outreach Activities
Participant of the outreach program of Center for Theoretical Biological Physics (CTBP) at UCSD. This program is sponsored by NSF to promote research interests in basic sciences among undergraduate and high school students particularly those in underrepresented groups. For example, I gave seminars in California State University, San Marcus (CSUSM), in which a significant number of students are from underrepresented groups.

Mentor of high school students, undergraduate and graduate students and postdoctoral students from underrepresented groups in my laboratory.
Selected Publications