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Aerial view of UCSD campus looking South

Geisel Library - Nobel Laureates at UCSD

Discovery of new atmospheric reaction garners prize

Urey Hall Addition

Pacific Hall

Natural Sciences Building

The crystal structure of a group II intron in the pre-catalytic state

Geisel Library Walk

York Hall

Structure of an inhibitor of hepatitis C virus protein synthesis bound to its target in the viral ribonucleic acid (RNA) genome

ANCA probe staining amyloid plaques derived from Alzheimer’s-related Aβ peptides fluoresces as green and as yellow when derived from prion proteins (PrPSC)

Price Center

Generation of bio-resistive surface coatings on amyloids inhibits harmful protein-amyloid interactions associated with Alzheimer disease

Proposed schematic models of the interfacial binding surface of four different members of the Phospholipase A2 superfamily

Urey Hall and Pacific Hall

Characterization of the "inhibitor binding pocket" in the catalytic domain of the calcium-independent phospholipase A2 with residues within a 5 A raidus of the inhibitor shown

A Crystalline Singlet Phosphinonitrene: a Nitrogen Atom Transfer Agent

Mayer Hall

Drug candidate in orange envelope bound to UPPS

Possible binding modes for phospholipase A2 via its membrane interaction site, another allosteric site, and its catalytic site



News

Prof. Grassian to receive 2018 AIC Chemical Pioneer Award in Philadelphia
Professor Vicki H. Grassian has been selected to receive the 2018 Chemical Pioneer Award by the American Institute of Chemists (http://www.theaic.org/awards_chem_pioneer.html). The award started in 1966 for the purpose of recognizing chemists, chemical engineers or their associates who have made outstanding contributions which have had a major impact on advances in the chemical science and industry and/or the chemical profession. Past award recipients include several UC San Diego Professor Harold Urey who received the award in 1969. Professor Grassian has been selected for this award for her significant contributions to the area of heterogeneous atmospheric chemistry and the emerging area of the environmental and health effects of nanomaterials. Her award addressed entitled “The Physical Chemistry of Environmental Interfaces” will be presented at the Science History Institute in Philadelphia on May 10, 2018. More Information...

Tezcan Lab creates a new form of material
All materials suffer from a fundamental limitation: If a substance is highly ordered, it tends to be inflexible and brittle. If it is highly flexible and adaptive, it tends to be disordered. Three graduate students in the Tezcan Lab, Ling Zhang, Jake Bailey and Rohit Subramanian, have circumvented this limitation by engineering a new material by integrating protein crystals with hydrogel polymers. These crystal-gel hybrids can reversibly expand by more than 500% in volume without losing crystalline order, resist fragmentation and self-heal efficiently, which conventional crystals are not capable of. The study is reported in the May 3rd issue of the journal Nature. More Information...

Congratulations to the 2018 recipients of the Frieda Daum Urey Endowed Fellowship!
We proudly announce that Khin San from the Schimpf Lab and Jessie Moreton from the Cohen Lab have been awarded the 2018 Frieda Daum Urey Endowed Fellowship!

Prof. Wei Xiong and his group receive 2018 DoD DURIP Award
Prof. Wei Xiong and his group receive 2018 DoD Defense University Research Instrumentation Program (DURIP) Award. The Xiong group will develop a tabletop time-resolved soft x-ray spectrometer under the support of this award. More Information...

Experiments and computation lead to the design & understanding of novel, responsive biomaterials
In a publication in Nature Chemistry, the collaborative team of the Tezcan Lab and Prof. Francesco Paesani report the first example of a synthetic protein assembly whose free energy landscape is fully mapped out by computation and experiment, and whose structural dynamics can be predictably engineered. To date, efforts in biomolecular design have overwhelmingly focused on obtaining inflexible architectures that assemble predominantly via high-affinity interactions into enthalpically favored structures. Led by Robert Alberstein, a graduate student in the Tezcan Lab, the team has now created 2D, porous protein lattices, whose dynamics are controlled by water entropy. Guided by computer simulations, the team has engineered the protein lattices to control their porosity in a predictable manner, which has important implications for applications in separation, filtration, sensing and catalysis. More Information...

Professor Kristie Boering Elected to U.S. National Academy of Sciences
Professor Kristie Boering, a 1985 graduate from our Department of Chemistry and Biochemistry, winner of the Harold C. Urey award for outstanding graduating senior was just elected to the U.S. National Academy. She did isotope research in Professor Thiemens group and received a PhD from Stanford University with Professor John Brauman. In her Post Doctoral research with Professor Steve Wofsy at Harvard she developed airborne and balloon instruments to study the global carbon cycle and flew missions around the world. She is presently a Professor at UC Berkeley in the Departments of Chemistry and Earth and Planetary Sciences with programs that isotopically study the nitrogen cycle, stratosphere-troposphere mixing, global change on long time scales and the earths and Titans early atmosphere using stable isotopes and global chemical modeling. Her work also includes basic photochemistry using crossed molecular beam and synchrotron UV light. More Information...

Congratulations to Chris Fisher, winner of the GSA Outstanding Graduate Student Leader Award!
Please show your support by joining us at the GSA Community Award Ceremony at the Loft Thursday, May 3rd from 4-6pm! All grads and faculty are welcome to attend.

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Faculty Spotlight

View profile for Amaro, Rommie
Amaro, Rommie

Computational Chemistry and Biophysics

View profile for Baker, Timothy
Baker, Timothy

Macromolecular, cryoelectron microscopy and three-dimensional, image-reconstruction techniques.

View profile for Brydges, Stacey
Brydges, Stacey

Chemical Education: Development of context-rich curriculum; Use of collaborative learning strategies in large lectures; Communication of chemistry

View profile for Burkart, Michael
Burkart, Michael

Natural product synthesis/biosynthesis, Biological chemistry and enzymology, Metabolic engineering.

View profile for Bussey, Thomas
Bussey, Thomas

Chemical Education: Visual Literacy in Science, Biochemistry Education, Nano Science Education, K-20 Professional Development, and STEM Career Development

View profile for Cohen, Seth
Cohen, Seth

Bioinorganic and coordination chemistry. Metalloprotein inhibitors and supramolecular materials.

View profile for Continetti, Robert
Continetti, Robert

Dissociation dynamics of transient species, three-body reaction dynamics, novel mass-spectrometric methods

View profile for Crowell, John
Crowell, John

Materials chemistry, surface kinetics of metals/semiconductors, CVD, photo-induced deposition, thin-film spectroscopy.

View profile for Debelouchina, Galia
Debelouchina, Galia

Chemical and spectroscopic approaches for structural biology of complex biological systems

View profile for Dennis, Edward
Dennis, Edward

Biochemistry: phospholipase A2, signal transduction in macrophages, lipid maps, prostaglandin regulation, mass spec of lipids and proteins.

View profile for Deshmukh, Lalit
Deshmukh, Lalit

Solution NMR spectroscopy, retroviruses, protein and nucleic acid biochemistry

View profile for Devaraj, Neal
Devaraj, Neal

Biomimetic Chemistry, Molecular Imaging, Chemical Biology

View profile for Dixon, Jack
Dixon, Jack

Protein Tyrosine Phosphatase, Dual=specific Phosphatase, PTEN

View profile for Donoghue, Daniel
Donoghue, Daniel

Fibroblast Growth Factor Receptors (FGFRs) in Human Cancer

View profile for Figueroa, Joshua
Figueroa, Joshua

Inorganic and Organometallic Chemistry: Synthesis, Small Molecule Activation and New Transformations.

View profile for Galperin, Michael
Galperin, Michael

Electron Transport in Condensed Phases. Dissipation and Relaxation Processes. Non-equilibrium Open Quantum Systems. Molecular Electronics.

View profile for Ghosh, Gourisankar
Ghosh, Gourisankar

Biochemistry and biophysics: transcription, signaling, pre-mRNA splicing, mRNA transport, protein-protein, protein-DNA and protein-RNA interactions

View profile for Ghosh, Partho
Ghosh, Partho

Mechanisms of bacterial and protozoan pathogenesis, and host response against infectious microbes.

View profile for Godula, Kamil
Godula, Kamil

Nanotechnologies for analysis of glycan function during development. Glycomaterials for stem cell-based tissue regeneration.

View profile for Grassian, Vicki
Grassian, Vicki

Surface science of complex environmental interfaces: heterogeneous atmospheric chemistry of sea spray and mineral dust; aerosol impacts on climate; applications and implications of nanoscience and nanotechnology.

View profile for Hermann, Thomas
Hermann, Thomas

RNA as a Drug Target and a Material for Nanotechnology

View profile for Jennings, Patricia
Jennings, Patricia

Biophysical chemistry: protein structure, dynamics and folding; 2, 3 and 4D NMR spectroscopy; PCR; equilibrium and kinetic-fluorescence, absorbance and circular dichroism spectroscopies

View profile for Joseph, Simpson
Joseph, Simpson

Molecular Mechanism of Protein Synthesis

View profile for Kim, Judy
Kim, Judy

Biophysical chemistry: Spectroscopic studies of membrane protein folding and dynamics

View profile for Klosterman, Jeremy
Klosterman, Jeremy

Playing with molecules in 3D

View profile for Komives, Elizabeth
Komives, Elizabeth

Structure, function, dynamics and thermodynamics of protein-protein interactions: NMR, mass spectrometry and kinetics

View profile for Komor, Alexis
Komor, Alexis

DNA damage and repair; Genome editing

View profile for Kubiak, Clifford
Kubiak, Clifford

Inorganic, materials, and physical chemistry: electron transfer, catalysis, fixation and utilization of carbon dioxide.

View profile for Kummel, Andrew
Kummel, Andrew

STM/STS of gate oxides on compound semiconductors and adsorbates on organic semiconductor

View profile for Lindenberg, Katja
Lindenberg, Katja

Theoretical chemical physics: non-equilibrium statistical mechanics; stochastic processes; nonlinear phenomena; complex systems; condensed matter.

View profile for McCammon, J. Andrew
McCammon, J. Andrew

Statistical mechanics and computational chemistry, with applications to biological systems

View profile for McHugh, Colleen
McHugh, Colleen

RNA-protein interactions; Assembly of RNPs; Structural biology of multimeric complexes

View profile for Molina, Mario
Molina, Mario

Physical Chemistry: Gas Phase Chemical Kinetics and Photochemistry; Chemistry of Atmospheric Aerosols; Air Pollution in Megacities of the Developing World

View profile for Molinski, Tadeusz
Molinski, Tadeusz

Organic chemistry of marine natural products, synthesis, NMR, and biomedical applications

View profile for Muller, Ulrich
Muller, Ulrich

Evolution of catalytic RNAs, and the Origin of Life

View profile for O'connor, Joseph
O'connor, Joseph

Organotransition metal; organic; physical organic; bioorganometallic; synthetic; and inorganic chemistry

View profile for Opella, Stanley
Opella, Stanley

NMR structural studies of proteins in membranes and other supramolecular assemblies

View profile for Paesani, Francesco
Paesani, Francesco

Theoretical chemical physics of complex interfaces of relevance to the environment

View profile for Perrin, Charles
Perrin, Charles

Physical-organic chemistry: stereoelectronic effects; hydrogen bonding; isotope effects; ionic solvation; naked anions; malonic anhydrides

View profile for Pomeroy, Robert
Pomeroy, Robert

The application of analytical chemistry to forensic, environmental and industrial chemistry, then bridge these experiences into the classroom. This also includes the role technology and instrumentation play in discovery and problem solving.

View profile for Prather, Kimberly
Prather, Kimberly

Environmental, physical/analytical chemistry: gas/particle processes of tropospheric significance; mass spectrometry; laser-based analysis techniques.

View profile for Rinehart, Jeffrey
Rinehart, Jeffrey

Inorganic, materials, and magnetochemistry

View profile for Sailor, Michael
Sailor, Michael

Nanomaterials: porous silicon, chemical and biological sensors, biomaterials, electrochemistry

View profile for Schimpf, Alina
Schimpf, Alina

Spectroscopy, Inorganic Chemistry, Nanoscale Materials

View profile for Schmidt, Valerie
Schmidt, Valerie

Organic Synthesis, Catalysis, Organometallic Synthesis, Methodology Development

View profile for Sinha, Amitabha
Sinha, Amitabha

Experimental physical chemistry: photochemistry; laser spectroscopy; reaction dynamics of vibrationally excited molecules

View profile for Tauber, Michael
Tauber, Michael

Physical chemistry; Optical and magnetic spectroscopy; Fundamental studies of charge transport and solvation; Applications to energy conversion and energy storage.

View profile for Taylor, Susan
Taylor, Susan

Structure, Function, Dynamics, and Localization of PKA as a Prototype for the Protein Kinase Superfamily.

View profile for Tezcan, Faik
Tezcan, Faik

Bioinorganic and biophysical chemistry; Metalloprotein structure, function and biosynthesis; Biomaterials

View profile for Theodorakis, Emmanuel
Theodorakis, Emmanuel

Synthetic, Medicinal, Bioorganic and Biological Chemistry, Methods and Strategies in Natural Products Chemistry

View profile for Thiemens, Mark
Thiemens, Mark

Atmospheric chemistry: physical chemistry of isotope effects; solar system formation

View profile for Toor, Navtej
Toor, Navtej

Structure and Function of Introns and Retroelements

View profile for Tor, Yitzhak
Tor, Yitzhak

Ligand-nucleic acid interactions; Antiviral and antibacterial agents; Fluorescent nucleosides and nucleotides; Cellular delivery vehicles

View profile for Wang, Wei
Wang, Wei

epigenomics, cellular reprogramming, protein recognition, computational biology, systems biology

View profile for Weare, John
Weare, John

Physical chemistry: calculations of the dynamics of complex systems; theoretical geochemistry

View profile for Weizman, Haim
Weizman, Haim

Chemical education, Bioorganic chemistry

View profile for Xiong, Wei
Xiong, Wei

Investigation of Charge Dynamics and Molecular Conformations at Interfaces

View profile for Yang, Jerry
Yang, Jerry

Bioorganic Chemistry, Molecular Self-Assembly, Molecular Synthesis, Materials Chemistry, Bionanotechnology

View profile for Yuen Zhou, Joel
Yuen Zhou, Joel

Molecular photonics: theory

View profile for Zid, Brian
Zid, Brian

Gene Expression Control During Stress; mRNA Localization to Membrane-Less Compartments


Events and Seminars

05/25/2018 (Fri) at 11:00 AM
Inorganic Seminar
Professor Jenny Y. Yang
(Bioinspired)Electrocatalysis for Renewable Fuels
05/29/2018 (Tue) at 11:00 AM
MS Thesis Defense
Alba Monferrer i Sureda
Versatile Kit of Nanoshapes Self-Assembling from RNA and DNA Modules
05/29/2018 (Tue) at 04:00 PM
Physical/Analytical Seminar
Professor Matthew Tucker
Vibrational Probe Pairs for Uncovering Structure and Dynamics within Biomolecules
05/30/2018 (Wed) at 12:00 PM
Thesis Defense
Christopher John Nalbandian
Catalytic Methods for Chemical Biology
05/31/2018 (Thu) at 10:00 AM
Thesis Defense
Christian Perez
Metal-Binding Pharmacophore Library Yields Discovery of Inhibitors for Rpn11 and Glyoxalase 1
05/31/2018 (Thu) at 01:00 PM
Thesis Defense
Sean Michael Maddox
Atropisomerism as Inspiration Towards the Development of New Chemical Methodologies
06/01/2018 (Fri) at 11:00 AM
Thesis Defense
Jean Sebastien Pradel
Optical Degenerate Four-Wave Mixing Spectroscopy for Characterizing and Quantifying Low Abundance Molecules/Agents in Complex Biological/Environmental Systems.
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