Cohen, Seth
Bioinorganic and coordination chemistry. Metalloprotein inhibitors and supramolecular materials.
Bioinorganic and coordination chemistry. Metalloprotein inhibitors and supramolecular materials.
Contact Information
Distinguished Professor, Department of Chemistry and Biochemistry
Chancellor's Distinguished Professorship in Chemistry and Biochemistry
Affiliate Faculty, Department of Nanoengineering
Office: Pacific Hall 4100A
Phone: 858-822-5596
Email: scohen@ucsd.edu
Web: cohenlab.ucsd.edu
Group: View group members
Chancellor's Distinguished Professorship in Chemistry and Biochemistry
Affiliate Faculty, Department of Nanoengineering
Office: Pacific Hall 4100A
Phone: 858-822-5596
Email: scohen@ucsd.edu
Web: cohenlab.ucsd.edu
Group: View group members
Education
1998 Ph.D., University of California, Berkeley
1994 B.S/B.A, Stanford University
1998 Ph.D., University of California, Berkeley
1994 B.S/B.A, Stanford University
Awards and Academic Honors
2022
IMPACT Award, Research Corporation for Scientific Advancement
2018
Freeman Lecturer, University of Sydney (Australia)
2017
TREE Award, Research Corporation for Scientific Advancement
2017
Chancellor's Award for Excellence in Postdoctoral Mentoring
2016
Arthur C. Cope Scholar Award, American Chemical Society
2015
Leslie E. Orgel Faculty Scholar
2015
Fellow, American Chemical Society
2014
Fellow, Royal Society of Chemistry
2013
Fellow, American Association for the Advancement of Science
2008
Roger Revelle Fellow, American Association for the Advancement of Science
2006
CAREER Award, National Science Foundation
2004
Cottrell Scholar Award, Research Corporation for Scientific Advancement
2001
Chris and Warren Hellman Faculty Scholar Award
Research Interests
Metalloprotein Inhibitors - Bioinorganic/Medicinal Chemistry
Several metalloenzymes are implicated in various diseases, including arthritis, heart disease, cancer, and others. Compounds containing ligands that bind to the catalytic metal ion in these metalloenzymes can act as effective inhibitors of potential therapeutic value. Our investigations focus on the design, synthesis, and evaluation of novel metalloprotein inhibitors based on new ligands for binding the active site metal ions.
Metal-Organic Frameworks - Inorganic/Materials Chemistry
We study the design, preparation, and properties of metal-organic frameworks (MOFs). MOFs are a class of advanced materials that may be useful in a variety of technological applications. We use organic chemistry to modify the surface and interior of MOFs in order to tune and optimize their physical and chemical properties.
Several metalloenzymes are implicated in various diseases, including arthritis, heart disease, cancer, and others. Compounds containing ligands that bind to the catalytic metal ion in these metalloenzymes can act as effective inhibitors of potential therapeutic value. Our investigations focus on the design, synthesis, and evaluation of novel metalloprotein inhibitors based on new ligands for binding the active site metal ions.
Metal-Organic Frameworks - Inorganic/Materials Chemistry
We study the design, preparation, and properties of metal-organic frameworks (MOFs). MOFs are a class of advanced materials that may be useful in a variety of technological applications. We use organic chemistry to modify the surface and interior of MOFs in order to tune and optimize their physical and chemical properties.
Primary Research Area
Inorganic Chemistry
Inorganic Chemistry
Interdisciplinary interests
Materials
Synthesis
Bioorganic
Synthesis
Bioorganic
Outreach Activities
Mentor for the Alliance for Graduate Education and Professoriate (AGEP) students, Sloan Scholars Program, UCDC Science Policy Internship Program (SPIP)
Image Gallery
Selected Publications See https://scholar.google.com/citations?user=UURO7YkAAAAJ&hl=en
- Mondal P, Neuschuler Z, Mandal D, Hernandez RE, Cohen SM "Reversible Postsynthetic Modification in a Metal-Organic Framework", Angew. Chem. Intl. Ed., 2024, e202317062
- Sikma RE, Cohen SM "Metal-Organic Frameworks with Zero and Low Valent Metal Nodes Connected by Tetratopic Phosphine Ligands", Angew Chem Int Ed, 2022, Vol. 61, e2021154
- Karges J,Kalaj M,Gembicky M,Cohen SM "ReI Tricarbonyl Complexes as Coordinate Covalent Inhibitors for the SARS-CoV-2 Main Cysteine Protease.", Angew Chem Int Ed Engl, 2021, Vol. 60, Issue 19, 10716-10723 [View]
- Kim JY, Barcus K, Cohen SM "Controlled Two-Dimensional Alignment of Metal-organic Frameworks in Polymer Films", J Am Chem Soc, 2021, Vol. 143, 3703-3706
- Semino R,Moreton JC,Ramsahye NA,Cohen SM,Maurin G "Understanding the origins of metal-organic framework/polymer compatibility.", Chem Sci, 2018, Vol. 9, Issue 2, 315-324 [View]