Deshmukh, Lalit
Solution NMR spectroscopy, Amyloids, Neurodegenerative diseases, Posttranslational modifications, Viruses
Solution NMR spectroscopy, Amyloids, Neurodegenerative diseases, Posttranslational modifications, Viruses
Contact Information
Associate Professor of Chemistry and Biochemistry
Office: Natural Sciences Bldg 3113
Phone: 858-246-3343
Email: ldeshmukh@ucsd.edu
Web: https://deshmukhgroup.ucsd.edu/
Group: View group members
Office: Natural Sciences Bldg 3113
Phone: 858-246-3343
Email: ldeshmukh@ucsd.edu
Web: https://deshmukhgroup.ucsd.edu/
Group: View group members
Education
2010 Ph.D., University of Connecticut
2004 B.Pharm, University of Pune, India
2010 Ph.D., University of Connecticut
2004 B.Pharm, University of Pune, India
Appointments
2024 - Present Associate Professor, University of California San Diego
2018 - 2024 Assistant Professor, University of California San Diego
2011 - 2017 Postdoctoral Fellow, National Institutes of Health
2024 - Present Associate Professor, University of California San Diego
2018 - 2024 Assistant Professor, University of California San Diego
2011 - 2017 Postdoctoral Fellow, National Institutes of Health
Awards and Academic Honors
2024
George W. and Carol A. Lattimer Faculty Research Fellowship
2021
Hellman Fellowship (Hellman Foundation)
2019
Collaborative Development Award (HIVE Center, TSRI)
2018
Gilead Sciences Research Scholars Award in HIV (Gilead Sciences, Inc.)
2018
Collaborative Development Award (CHEETAH Center, University of Utah)
2012
Nancy Nossal Fellowship Award (NIDDK, NIH)
2009
Richardson-Vicks / A. Francis Summa Memorial Award (University of Connecticut)
Research Interests
Biophysical Characterization of Protein Structure, Dynamics, and Function.
Primary Research Area
Biochemistry
Biochemistry
Interdisciplinary interests
Biophysics
Macromolecular Structure
Cellular Biochemistry
Macromolecular Structure
Cellular Biochemistry
Selected Publications
- Elias RD,Zhu Y,Su Q,Ghirlando R,Zhang J,Deshmukh L "Reversible phase separation of ESCRT protein ALIX through tyrosine phosphorylation.", Sci Adv, 2023, Vol. 9, Issue 28, eadg3913 [View]
- Nelson SL,Li Y,Chen Y,Deshmukh L "Avidity-based method for the efficient generation of monoubiquitinated recombinant proteins.", J Am Chem Soc, 2023, [View]
- Shihora A,Elias RD,Hammond JA,Ghirlando R,Deshmukh L "ALS Variants of Annexin A11's Proline-Rich Domain Impair Its S100A6-Mediated Fibril Dissolution.", ACS Chem Neurosci, 2023, [View]
- Yu C,Nelson SL,Meisl G,Ghirlando R,Deshmukh L "Phase Separation and Fibrillization of Human Annexin A7 Are Mediated by Its Proline-Rich Domain.", Biochemistry, 2023, [View]
- Elias RD,Ramaraju B,Deshmukh L "Mechanistic roles of tyrosine phosphorylation in reversible amyloids, autoinhibition, and endosomal membrane association of ALIX.", J Biol Chem, 2021, 101328 [View]
- Ramaraju B,Nelson SL,Zheng W,Ghirlando R,Deshmukh L "Quantitative NMR study of insulin-degrading enzyme using amyloid-β and HIV-1 p6 elucidates its chaperone activity.", Biochemistry, 2021, [View]
- Elias RD,Ma W,Ghirlando R,Schwieters CD,Reddy VS,Deshmukh L "Proline-rich domain of human ALIX contains multiple TSG101-UEV interaction sites and forms phosphorylation-mediated reversible amyloids.", Proc Natl Acad Sci U S A, 2020, [View]