Ghosh, Partho
Mechanisms of bacterial and protozoan pathogenesis, and host response against infectious microbes.
Mechanisms of bacterial and protozoan pathogenesis, and host response against infectious microbes.
Contact Information
Professor of Chemistry and Biochemistry
Office: Natural Sciences Bldg 3105
Phone: 858-822-1139
Email: pghosh@ucsd.edu
Web: pghosh.ucsd.edu
Group: View group members
Office: Natural Sciences Bldg 3105
Phone: 858-822-1139
Email: pghosh@ucsd.edu
Web: pghosh.ucsd.edu
Group: View group members
Education
1992 Ph. D., University of California, San Francisco
1985 B.S., Yale University
1992 Ph. D., University of California, San Francisco
1985 B.S., Yale University
Appointments
1997 Postdoc, Harvard University
1997 Postdoc, Harvard University
Awards and Academic Honors
2000
Burroughs-Wellcome New Initiatives in Malaria
1999
W. M. Keck Distinguished Young Scholar in Medicine
1999
Hellman Faculty Fellow
Research Interests
Research in my laboratory is dedicated to understanding the basis of infectious disease at molecular and cellular levels. We focus on mechanisms by which virulence factors produced by pathogenic microbes interact with host cell targets and thereby modulate host cell behavior during infection. We study these interactions in structural detail (i.e., at the level of atomic resolution through X-ray crystallography) in order to carry out precise biochemical, genetic, and cell biological experiments aimed at elucidating the mechanism of action of bacterial virulence factors in their cellular and organismal contexts.
Primary Research Area
Biochemistry
Biochemistry
Interdisciplinary interests
Biophysics
Macromolecular Structure
Cellular Biochemistry
Macromolecular Structure
Cellular Biochemistry
Outreach Activities
Mentor for UCSD undergraduate and students.
Mentor for Summer Training Academy for Research in the Sciences (STARS) students.
Seminars at Southwestern College (community college), Chula Vista, CA, for American Chemical Society Association of Undergraduate Students.
Mentor for high school student as part of the UCSD Research Scholar Program.
Mentor for Summer Training Academy for Research in the Sciences (STARS) students.
Seminars at Southwestern College (community college), Chula Vista, CA, for American Chemical Society Association of Undergraduate Students.
Mentor for high school student as part of the UCSD Research Scholar Program.
Image Gallery
Selected Publications
- Valderrama JA,Riestra AM,Gao NJ,LaRock CN,Gupta N,Ali SR,Hoffman HM,Ghosh P,Nizet V "Group A streptococcal M protein activates the NLRP3 inflammasome.", Nat Microbiol, 2017, Vol. 2, Issue 10, 1425-1434 [View]
- Buffalo CZ,Bahn-Suh AJ,Hirakis SP,Biswas T,Amaro RE,Nizet V,Ghosh P "Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein.", Nat Microbiol, 2016, Vol. 1, Issue 11, 16155 [View]
- Stewart CM,Buffalo CZ,Valderrama JA,Henningham A,Cole JN,Nizet V,Ghosh P "Coiled-coil destabilizing residues in the group A Streptococcus M1 protein are required for functional interaction.", Proc Natl Acad Sci U S A, 2016, Vol. 113, Issue 34, 9515-20 [View]
- Alayyoubi M,Guo H,Dey S,Golnazarian T,Brooks GA,Rong A,Miller JF,Ghosh P "Structure of the essential diversity-generating retroelement protein bAvd and its functionally important interaction with reverse transcriptase.", Structure, 2013, Vol. 21, Issue 2, 266-76 [View]
- Macheboeuf P, Buffalo C, Fu CY, Zinkernagel AS, Cole JN, Johnson JE, Nizet V, Ghosh P, "Streptococcal M1 protein constructs a pathological host fibrinogen network.", Nature, 2011, Vol. 472, Issue 7341, 64-8 [View]
- McNamara C, Zinkernagel AS, Macheboeuf P, Cunningham MW, Nizet V, Ghosh P, "Coiled-coil irregularities and instabilities in group A Streptococcus M1 are required for virulence.", Science, 2008, Vol. 319, Issue 5868, 1405-8 [View]
- Miller JL, Le Coq J, Hodes A, Barbalat R, Miller JF, Ghosh P, "Selective ligand recognition by a diversity-generating retroelement variable protein.", PLoS Biol, 2008, Vol. 6, Issue 6, e131 [View]
- Rodgers L, Gamez A, Riek R, Ghosh P, "The type III secretion chaperone SycE promotes a localized disorder-to-order transition in the natively unfolded effector YopE.", J Biol Chem, 2008, Vol. 283, Issue 30, 20857-63 [View]
- McMahon SA, Miller JL, Lawton JA, Kerkow DE, Hodes A, Marti-Renom MA, Doulatov S, Narayanan E, Sali A, Miller JF, Ghosh P, "The C-type lectin fold as an evolutionary solution for massive sequence variation.", Nat Struct Mol Biol, 2005, Vol. 12, Issue 10, 886-92 [View]
- Banerjee M, Copp J, Vuga D, Marino M, Chapman T, van der Geer P, Ghosh P, "GW domains of the Listeria monocytogenes invasion protein InlB are required for potentiation of Met activation.", Mol Microbiol, 2004, Vol. 52, Issue 1, 257-71 [View]
- Phillips RM, Six DA, Dennis EA, Ghosh P, "In vivo phospholipase activity of the Pseudomonas aeruginosa cytotoxin ExoU and protection of mammalian cells with phospholipase A2 inhibitors.", J Biol Chem, 2003, Vol. 278, Issue 42, 41326-32 [View]
- Birtalan SC, Phillips RM, Ghosh P, "Three-dimensional secretion signals in chaperone-effector complexes of bacterial pathogens.", Mol Cell, 2002, Vol. 9, Issue 5, 971-80 [View]
- Marino M, Banerjee M, Jonquières R, Cossart P, Ghosh P, "GW domains of the Listeria monocytogenes invasion protein InlB are SH3-like and mediate binding to host ligands.", EMBO J, 2002, Vol. 21, Issue 21, 5623-34 [View]