Charles Perrin

Education

A.B.scl - Harvard (1959)

Ph.D. - Harvard (1963)

Awards and Academic Honors

Coming soon!

Primary Research Area

• Organic Chemistry
• Physical Chemistry
• SMCB
• Analytical & Atmospheric Chemistry

Interdisciplinary Interests

Coming soon!

Selected Publications

1. Perrin, C. L., "Is There Stereoelectronic Control in Formation and Cleavage of Tetrahedral Intermediates?", Acc. Chem. Res. (2002), 35, 28-34. (2002)

2. Perrin, C. L.; Ohta, B. K.; Kuperman, J.; Liberman, J.; Erdélyi, M. "Stereochemistry of beta-Deuterium Isotope Effects on Amine Basicity", J. Am. Chem. Soc. (2005), 127, 9641-9647. (2005)

3. Perrin, C. L.; Dong, Y. "Secondary Deuterium Isotope Effects on Acidity of Carboxylic Acids and Phenols", J. Am. Chem. Soc. (2007), 129, 4490-4497. (2007)

4. Perrin, C. L.; Rodgers, B. L.; O'Connor, J. M. "Nucleophilic Addition to a p-Benzyne Derived from an Enediyne: A New Mechanism for Halide Incorporation into Biomolecules" J. Am. Chem. Soc. (2007), 129, 4795-4799. (2007)

5. Perrin, C. L.; Zhao, C. "Intramolecular Kinetic Isotope Effect in Hydride Transfer from Dihydroacridine to a Quinolinium Ion. Rejection of a Proposed Two-Step Mechanism with a Kinetically Significant Intermediate", Org. Biomol. Chem., (2008), 6, 3349-3353. (2008)

6. Perrin, C. L.; Flach, A. "No Contribution of an Inductive Effect to Secondary Deuterium Isotope Effects on Acidity" Angew. Chem. 2011, 50,7674.

7. Perrin, C. L. "Are Short, Low-Barrier Hydrogen Bonds Unusually Strong?" Acc. Chem. Res., 2010, 43, 1550.

8. Perrin, C. L.; Lau, J. S.; Kim, Y.-J.; Karri, P.; Moore, C.; Rheingold,A. L. "Asymmetry of the 'Strongest' OHO Hydrogen-Bond, in the Monoanion of (±)-a,a'-Di-tert-butylsuccinate", J. Am. Chem. Soc., 2009, 131, 13548; 2010, 132, 2099

9. J Am Chem Soc (2012) , Vol. 134 , No. 23 , pp. 9698-707

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10. J Am Chem Soc (2012) , Vol. 134 , No. 18 , pp. 7766-72

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11. J. Phys. Org. Chem. (2013) , Vol. 26 , pp. 206-210

12. J. Am. Chem. Soc. (2014) , Vol. 136 , pp. 4355-4362

13. J. Am. Chem. Soc. (2014) , Vol. 136 , pp. 15263-15269

14. J. Phys. Org. Chem. (2015) , Vol. 28 , pp. 203-209

15. J. Phys. Org. Chem. (2013) , Vol. 26 , pp. 269-270

16. J. Am. Chem. Soc (2014) , Vol. 136 , pp. 15481-15484

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17. New J. Chem (2015) , Vol. 39 , pp. 1517-1521

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18. J. Phys. Chem. A (2015) , Vol. 119 , pp. 5009-5018

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19. Isr. J. Chem.DOI: 10.1002/ijch.201500027 (2016) , Vol. 56 , No. 56 , pp. 46-52

20. J Org Chem (2016)

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21. Journal of Chemical Education (2017) , Vol. 94 , pp. 669-672

22. Methods Enzymol (2017) , Vol. 596 , pp. 331-368

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23. ACS Symposium Series (2017) , Vol. 1262 , pp. 243-259

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24. Magn Reson Chem (2018)

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25. Chem Sci (2018) , Vol. 9 , No. 7 , pp. 1789-1794

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26. J Am Chem Soc (2019) , Vol. 141 , No. 9 , pp. 4103-4107

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27. J. Am. Chem. Soc (2019) , Vol. 141 , pp. 17278

28. Chemical Science (2020) , Vol. 11 , pp. 8489-8494

29. Org.Lett. (2021) , Vol. 23 , pp. 6911-6915

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30. J. Org. Chem. (2021) , Vol. 86 , pp. 14245?14249

31. Journal of Organic Chemistry (2022)

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32. J Phys Org Chem (2021)

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33. Pure Appl. Chem (2022) , Vol. 94 , pp. 353–534

34. Phys. Chem. Chem. Phys. (2021) , Vol. 23 , pp. 22199-22201

35. ACS Omega (2022)

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36. PhysChemChemPhys (2022)

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37. Physical Chemistry Chemical Physics (2022) , Vol. 23 , pp. 18978 - 18982

38. Molecules (2023) , Vol. 28 , pp. 4462-4491

39. J. Org. Chem (2025) , Vol. 90 , pp. 3809–3813

40. J. Org. Chem (2025) , Vol. 90 , pp. 8445-8456

41. J. Org. Chem (2026) , Vol. 91 , pp. 3342-3346

42. J. Chem. Ed. (2026)